A series of murders in the West End of London baffle the officers of Scotland Yard and draw the interest of a crime reporter to the case.

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A slum girl saves her benefactor's son from tricksters.

American newspaper reporter Jim Crocker's madcap escapades in London earn him notoriety and the nickname "Piccadilly Jim." When he overhears his American cousin by marriage, Ann Chester, giving her candid opinion of him, he decides to return to America to try to reform. He meets Ann on the boat, using another name. Unable to find work in New York, he goes to his step aunt Mrs. Peter Pett's home to be near Ann. Jim then helps Ann kidnap pampered cousin Ogden Pett whose overindulgence has created disruption in the household.

Jim's father wants to marry Eugenia, but her sister Netta refuses to allow it. When Jim sees Ann at a club, he falls for her even though she is with Lord Priory. He meets her the next day at the riding path, but she quickly loses him. He searches all over for her, not knowing that his father's hopeful fiancée is her Aunt. As his caricature work suffers as he searches, he is fired from his paper. But he makes a comeback with the comics 'Rags to Riches' which is based upon the Pett's. But this upsets the Pett's so much that they go back to New York, and he follows, being careful not to let them know that he is the one who draws the strip that parodies them.

Anna Neagle plays a patriotic young British girl who joins the WRENS when war breaks out. She marries Michael Wilding, the son of an nobleman. Neagle is shipped off to Singapore and is presumed killed in action. Wilding's grief is assuaged when he meets American WAVE Frances Mercer. He remarries, and the couple have a child. But Neagle is not dead, merely marooned on a desert island. Upon returning to civilization, Neagle glimpses her husband and his new family, tearfully realizes that there's no place for her in his new life, and is promptly blown to bits in an air raid. A weeper deluxe, Piccadilly Incident was an unusually morose effort for Anna Neagle and her producer-husband Herbert Wilcox. Casting notes: Michael Wilding was third choice for the leading man after Rex Harrison and John Mills, while Frances Mercer was a last-minute replacement for Marsha Hunt.

A playboy tries to recruit a gang, who include an American who needs cash to satisfy his wife's expensive tastes, and an old time expert cracksman, to rob a foreign embassy's safe, but trouble starts when the plan begins to go wrong.

A view of Piccadilly Circus in London.

An aspiring singer, a troubled rich boy, and an ex-seminarian share an apartment in the East Village in this story dealing with AIDS, sexuality, and living in NYC of the late '80s.